563 pages : 27 cm

This volume explores research on marijuana-like substances produced naturally by the human body and brain. These endogenous lipid molecules, or endocannabinoids, constitute a uniquely conserved and ubiquitous physiological control system in a variety of species and plays fundamental roles in development and cell death. The authors discuss this progress in marijuana research including identification of genes encoding endocannabinoid receptors, isolation of endocannabinoids and entourage ligands, and functional identification of transporters and enzymes for the biosynthesis and degradation of these endogenous substances

Includes bibliographical references and index

pt. I. Historical aspects and chemistry. Look back in Ananda -- 40 years of research on cannabinoids / Raphael Mechoulam -- The relationship between endocannabinoid conformation and endocannabinoid interaction at the cannabinoid receptors / Patricia H. Reggio -- pt. II. Cannabinoid receptor genetics and signal transduction. Endocannabinoid receptor genetics and marijuana use / Emmanuel S. Onaivi [and others] -- Endocannabinoids and intracellular signaling / sean D. McAllister and Mary E. Abood -- Endocannabinoids as retrograde messengers in synaptic transmission / Saori Oka [and others] -- Non-CB1, non-CB2 receptors for endocannabinoids / Vincenzo Di Marzo and Luciano De Petrocellis -- pt. III. Biochemistry of the endocannabinoid system. Occurrence, biosynthesis, and metabolism of endocannabinoids / Takayuki Sugiura [and others] -- Endocannabinoids and eicosanoids: all in the family / Sumner Burstein -- pt. IV. Endocannabinoids in CNS physiology. Man-made marijuana: endocannabinoid modulation of synaptic transmission and implications for the regulation of synaptic plasticity / Alexander F. Hoffman and Carl R. Lupica

Cannabinoids and the cetral serotonergic system / Marisela Morales -- Endocannabinoids and dopamine-related functions in the CNS / Javer Fernandez-Ruiz [and others] -- Pharmacology of the oxidative metabolities of endocannabinoids / Ruth A. Ross -- Behavioral effects of endocannabinoids / Marie-Helene Thiebot [and others] -- pt. V. Endocannabinoids in CNS pathology. Neuroprotection: glutamate and endocannabinoids / Harald S. Hansen, Gitte Petersen, and Henrik H. Hansen -- Neuropsychiatry: schizophrenia, depression, and anxiety / Ester Fride and Ethan Russo -- The role of endocannabinoids in the development, progression, and treatment of neruodegenerative diseases / Michelle Glass -- pt. VI. Endocannabinoids in peripheral organ systems. Endocannabinoids and gastrointestinal function / Nissar A. Darmani -- Endocannabinoids and the cardiovascular system / Michael D. Randall -- Endocannabinoids in inflammation and immune response / Evgeny V. Berdyshev

Envolvement of the endocannaboind system in cancer / Mauro Maccarrone -- Endocannabinoids and endocrine function / Laura L. Murphy -- Endocannabinoids in fertilization, pregnancy, and development / Herbert Schuel and Lani J. Burkman -- pt. VII. Endocannabinoid phylogenetics. Distribution of endocannabinoids and their receptors and enzymes on the Tree of Life -- pt. VIII. Perspective. Endocannabinoid-based molecules as potential therapeutic drugs / Alessia Ligresti and Vincenzo Di Marco

plus-circle Add Review

comment

Reviews